Knowledge in Motion: A decade reviewed, a future defined – The ABC Global Alliance 2015–2025 Decade Report and 2025–2035 Global Charter

Breast cancer remains one of the most significant global health challenges, with approximately 2.3 million new cases diagnosed and 666,000 deaths every year. Advanced breast cancer (ABC) - encompassing locally advanced and metastatic disease - represents the leading cause of breast cancer-related mortality and morbidity worldwide. While early-stage breast cancer has seen remarkable improvements in survival rates in the past decade, outcomes for individuals with ABC remain sobering: only 32 % of women diagnosed with ABC survive five years post-diagnosis, and this figure drops to just 20 % for men. The ABC Global Alliance was established in 2016 as a multi-stakeholder platform dedicated to advanced/metastatic breast cancer. Its vision: to improve and extend the lives of women and men living with ABC in all countries worldwide and to fight for a cure. This special edition of The Breast is both a reflection on the past decade of progress across the ABC landscape, and a forward-looking roadmap for the future. It summarizes findings from the ABC Global Alliance's Global Decade Report 2.0 (2015-2025) and the newly defined ten goals set out in the 2025-2035 ABC Global Charter 2.0, signaling a renewed commitment to advancing ABC care globally over the next decade.