Opportunistic screening for broad range of medically relevant secondary findings: Laboratory benefits and burdens

Although the yield of reportable SFs was high, this was accompanied by many nonreportable VUS and increased efforts for exome analysis.

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Publication Details

Journal
Genetics in Medicine
Published
2025-10-15
DOI
https://doi.org/10.1016/j.gim.2025.101599
Primary Topic
Meta-analysis and systematic reviews
Type
article
Field-Weighted Citation Impact
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article

Opportunistic screening for broad range of medically relevant secondary findings: Laboratory benefits and burdens

Sonya Grewal, Nicole Forster, Daena Hirjikaka, Kelvin Chan et al.
Genetics in Medicine
Meta-analysis and systematic reviews
article

Opportunistic screening for broad range of medically relevant secondary findings: Laboratory benefits and burdens

Sonya Grewal, Nicole Forster, Daena Hirjikaka, Kelvin Chan, Yael Silberman, Kasmintan A. Schrader, Kevin E. Thorpe, Yvonne Bombard, Rita Kodida, Thomas Ward, Jordan P. Lerner‐Ellis, Susan Randall Armel, Tracy Graham, Chantal F. Morel, Salma Shickh, Christine Elser, Abdul Noor, José‐Mario Capo‐Chichi, Raymond H. Kim, Iris Cohn, Andrea Eisen, Marc Clausen, Carolyn Piccinin, Elena Greenfeld, Melyssa Aronson, Jordan Sam, Seema Panchal, Emma Reble, Chloe Mighton, Larissa Peck, Emily Glogowksi
article en

Abstract

Although the yield of reportable SFs was high, this was accompanied by many nonreportable VUS and increased efforts for exome analysis.

Genetics in MedicineVol. 28(4)
BC Cancer Agency (CA), Mount Sinai Hospital (CA), St. Michael's Hospital (CA), Sunnybrook Health Science Centre (CA), University Health Network (CA), University of Toronto (CA), Hospital for Sick Children (CA), Health Sciences Centre (CA), Princess Margaret Cancer Centre (CA), Sanofi (United States) (US), Public Health Ontario (CA), Sinai Health System (CA), Unity Health Toronto
Openalex Percentile: Top 71%
Meta-analysis and systematic reviews
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