First-Trimester mRNA COVID-19 Vaccination and Risk of Major Congenital Anomalies
In this cohort study of pregnancies exposed to mRNA COVID-19 vaccines in the first trimester, exposure was not associated with an increased risk of any MCMs, overall, by organ group, or by individual MCM, supporting the safety of mRNA COVID-19 vaccines in early pregnancy.
Authors
- Sara Souto‐Miranda (ORCID: https://orcid.org/0000-0002-5984-4844)
- Jérôme Drouin (ORCID: https://orcid.org/0000-0003-2017-7041)
- Laurent Chouchana (ORCID: https://orcid.org/0000-0002-9626-3571)
- Rosemary Dray‐Spira (ORCID: https://orcid.org/0000-0001-7646-3667)
- Laura Semenzato (ORCID: https://orcid.org/0000-0002-8305-3487)
- Mahmoud Zureik (ORCID: https://orcid.org/0000-0002-8393-4217)
- Jérémie Botton (ORCID: https://orcid.org/0000-0002-4814-6370)
- Alain Weill (ORCID: https://orcid.org/0000-0001-8687-9092)
- Cécilia Bernard
- Lise Marty (ORCID: https://orcid.org/0000-0001-8496-5886)
- Tom Duchemin
Institutions
- Conservatoire National des Arts et Métiers (FR)
- Inserm (FR)
- Université Paris-Saclay (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale (FR)
- Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (FR)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.38039
- Citations
- 2
- Primary Topic
- COVID-19 Impact on Reproduction
- Type
- article
- Field-Weighted Citation Impact
- 4.11