A new isoflavone glycoside from the stems of <i>Eclipta prostrata</i> (L.) L. with glycosidase inhibitory activity
A new isoflavone glycoside, prostratanoside A (<b>1</b>), along with four known compounds (<b>2-5</b>), was isolated from the stems of <i>Eclipta prostrata</i> (L.) L. Their structures were elucidated through comprehensive spectroscopic (NMR and MS) and physicochemical analyses. All isolated compounds were evaluated for their <i>in vitro</i> α-glucosidase inhibitory activity. Notably, compound <b>1</b> displayed the most potent inhibition, with an IC<sub>50</sub> value of 10.3 ± 1.2 μM. Besides, the potential binding sites of <b>1</b> were predicted by molecular docking.
Authors
- Xuefeng Wu (ORCID: https://orcid.org/0000-0001-7932-4507)
- Hao Xu (ORCID: https://orcid.org/0009-0008-4323-5623)
- Yuan Gao (ORCID: https://orcid.org/0000-0002-1114-1197)
- Long Cui (ORCID: https://orcid.org/0000-0002-4106-6319)
- Ying-Xiao Xiao
- Yilin Li (ORCID: https://orcid.org/0000-0003-3800-3883)
- Hyun Sun Lee
Institutions
- Beihua University (CN)
- Korea Research Institute of Bioscience and Biotechnology (KR)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1080/14786419.2025.2572536
- Primary Topic
- Medicinal Plants and Neuroprotection
- Type
- article
- Field-Weighted Citation Impact
- 0.00