Leveraging Medulloblastoma Clonal Dynamics to Overcome Treatment Resistance
This work provides the foundation for clinical validation of small-molecule inhibitors synergistic with PTC596 to improve the durability of remissions and extend the survival of patients with treatment-refractory group 3 medulloblastoma.
Authors
- Chitra Venugopal (ORCID: https://orcid.org/0009-0000-2968-2971)
- Sheila Kumari Singh (ORCID: https://orcid.org/0000-0003-1272-5300)
- Maleeha Qazi (ORCID: https://orcid.org/0000-0001-8350-1094)
- Laura Escudero (ORCID: https://orcid.org/0000-0001-7385-673X)
- Muhammad Vaseem Shaikh (ORCID: https://orcid.org/0009-0009-6929-1209)
- David Tieu
- Dillon McKenna (ORCID: https://orcid.org/0009-0000-6803-9786)
- Kui Zhai (ORCID: https://orcid.org/0000-0003-4725-190X)
- Stefan Custers (ORCID: https://orcid.org/0009-0007-3297-8918)
- Marla Weetall (ORCID: https://orcid.org/0000-0002-2013-8096)
- Chirayu Chokshi (ORCID: https://orcid.org/0000-0003-0831-0217)
- Ashley Adile (ORCID: https://orcid.org/0000-0002-3700-7527)
- Kevin R. Brown (ORCID: https://orcid.org/0000-0002-5514-2538)
- Katherine Chan (ORCID: https://orcid.org/0009-0000-7513-5880)
- David Bakhshinyan (ORCID: https://orcid.org/0000-0002-1917-7354)
- Jason Moffat (ORCID: https://orcid.org/0000-0002-5663-8586)
- Yujin Suk (ORCID: https://orcid.org/0000-0002-3966-3771)
- Hardikkumar Patel
Institutions
- University of Toronto (CA)
- McMaster University Medical Centre (CA)
- Hospital for Sick Children (CA)
- Population Health Research Institute (CA)
- Amgen (Canada) (CA)
- PTC Therapeutics (United States) (US)
- Hamilton Health Sciences (CA)
- McMaster University (CA)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-4010
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00