The Impact of Hepatoprotective Correction on the Course of Odontogenic Inflammatory Processes of the Maxillofacial Region

Annotation. The treatment of odontogenic phlegmons of the maxillofacial region remains an important issue in maxillofacial surgery due to their increasing incidence and severe complications. The presence of hepatobiliary disorders further complicates the course of dental diseases, as evidenced by alterations in biochemical markers in oral fluid under such conditions. Therefore, the analysis of saliva is reasonable for selecting appropriate pharmacological support during treatment. The aim of the study was to evaluate the effect of hepatoprotective correction in the complex treatment of odontogenic inflammatory processes of the maxillofacial region in patients with hepatobiliary system pathology. The study included three groups: Control group – 10 healthy patients who underwent standard treatment after incision of submandibular phlegmon; Comparison group – 12 patients with hepatobiliary pathology who received standard therapy; Main group – 15 patients with hepatobiliary diseases who, in addition to standard treatment, were prescribed Glutargin and Inflarax ointment. The standard treatment scheme for the control and comparison groups included: antibacterial therapy, analgesics, antihistamines, vitamin supplementation, and local ointment dressings with Levomecol. The treatment scheme for the main group additionally included the hepatoprotective drug Glutargin and topical application of Inflarax ointment. In all groups, the functional state of the liver was assessed by determining enzyme activity in oral fluid (elastase, acid phosphatase), as well as the degree of dysbiosis. Our study demonstrated that liver damage is accompanied by disturbances in oral fluid parameters, closely associated with the development of several pathochemical changes, in particular activation of inflammatory responses and suppression of vasculogenesis processes in the oral mucosa. At the same time, the use of glutamic acid arginine in combination with Inflarax proved effective in improving oral fluid indicators due to its hepatoprotective activity and anti-inflammatory properties.