Effectiveness of the Use of a Therapeutic and Preventive Complex in the Treatment of Patients with Oral Mucosal Lichen Planus

Annotation. Despite numerous clinical and experimental studies, the problem of treating oral mucosal lichen planus remains relevant. Addressing the issues of treatment and prevention of the progression of one form of oral lichen planus into another is an urgent healthcare problem, bearing not only medical but also significant economic importance, since such patients often require prolonged hospitalization. The aim of our study was to evaluate the effectiveness of the proposed therapeutic and preventive complex in the treatment of patients with oral mucosal lichen planus. Our observations included 27 patients with the erosive-ulcerative form of lichen planus (22 women and 5 men), aged 24 to 74 years. We assessed the enzymatic activity in oral fluid on the first day after the onset of erosions and ulcers, as well as on the 14th and 30th days of treatment. In oral lichen planus, it is advisable to use agents that reduce inflammation, normalize immunological reactivity, decrease free radical lipid peroxidation, and eliminate dysbiosis (by 7.7 times). The application of the therapeutic and preventive complex contributed to a decrease in lipid peroxidation processes, as evidenced by a significant reduction in malondialdehyde levels and an increase in the activity of the antioxidant enzyme catalase. The treatment of oral lichen planus should therefore be comprehensive and etiopathogenetic.