PAK6 drives tumor microenvironment remodeling in nasopharyngeal carcinoma with lymph node necrosis: implications for distant metastasis and survival
These findings highlight LNN as a critical prognostic factor in NPC and suggest that PAK6 could be a promising therapeutic target for improving treatment outcomes in NPC patients.
Authors
- Sufang Qiu (ORCID: https://orcid.org/0000-0001-7660-6955)
- Wei Xu (ORCID: https://orcid.org/0000-0003-3808-0045)
- Yirong Su (ORCID: https://orcid.org/0000-0001-6864-3510)
- Xiuhua Li (ORCID: https://orcid.org/0000-0003-4386-8419)
- Xin Chen (ORCID: https://orcid.org/0000-0002-2628-4027)
- Honghong Zhang (ORCID: https://orcid.org/0000-0002-3893-5763)
- Junping Pan
- Xiaochuan Chen (ORCID: https://orcid.org/0000-0002-5720-7657)
- Yuhao Lin (ORCID: https://orcid.org/0009-0007-9288-8551)
- Shunqing Xu (ORCID: https://orcid.org/0009-0004-0126-2034)
- Ching-Hsiung Lin (ORCID: https://orcid.org/0000-0003-0512-4953)
Institutions
- Fujian Medical University (CN)
- Xiamen University (CN)
- Fujian Provincial Cancer Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.intimp.2025.115662
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00