Generation of induced pluripotent stem cell line UJSi005-A from developmentally delayed schizophrenic patients
Schizophrenia, a chronic mental health condition, is characterized by abnormalities in perception, emotions and behavior. We successfully generated induced pluripotent stem cells (iPSCs) from the peripheral blood mononuclear cells (PBMCs) of a patient with schizophrenia and neurodevelopmental delay who responded well to olanzapine therapy. The iPSCs exhibited a normal karyotype, expressed markers of undifferentiated human pluripotent stem cells (hPSCs), and differentiated into the three germ layers in vivo.
Authors
- Tonglu Qiu (ORCID: https://orcid.org/0000-0002-7876-337X)
- Bing Xue (ORCID: https://orcid.org/0000-0002-2341-3460)
- Shengying Qin (ORCID: https://orcid.org/0000-0002-8458-5960)
- Bonan Chen (ORCID: https://orcid.org/0000-0002-2430-7934)
- Xuan Xu (ORCID: https://orcid.org/0000-0003-4908-8501)
- Yupeng Wang (ORCID: https://orcid.org/0000-0002-9723-7287)
- Jing Sun (ORCID: https://orcid.org/0000-0001-7097-9590)
- Wenzhuo Zhao
- Dingqi Zhang
- Zhenghua Shan
Institutions
- Jiangsu University (CN)
- Ministry of Education (TH)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.scr.2025.103854
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00