Risk factors for persistent candidemia and prognostic implications: Results from the ECMM Candida III study
Persistent candidemia was predicted by poor adherence to treatment guidelines, as shown by low EQUAL Candida Scores, particularly due to the lack of initial echinocandin use. After controlling immortal time bias, persistent candidemia ≥5 days and ICU admission remained independent predictors of mortality in the multivariable model.
Authors
- Halis Akalın (ORCID: https://orcid.org/0000-0001-7530-1279)
- Benedict Rogers (ORCID: https://orcid.org/0000-0002-7041-6744)
- Subhra K. Biswas
- Eelco F. J. Meijer (ORCID: https://orcid.org/0000-0002-0226-024X)
- P. Lewis White (ORCID: https://orcid.org/0000-0003-3056-4205)
- Aleksandra Barać (ORCID: https://orcid.org/0000-0002-0132-2277)
- Ana Alastruey‐Izquierdo (ORCID: https://orcid.org/0000-0001-8651-4405)
- Deniz Akyol (ORCID: https://orcid.org/0000-0002-1644-6248)
- Małgorzata Mikulska (ORCID: https://orcid.org/0000-0002-5535-4602)
- Jean‐Pierre Gangneux (ORCID: https://orcid.org/0000-0002-4974-5607)
- Maite Ruíz-Pérez de Pipaón (ORCID: https://orcid.org/0000-0003-4876-0896)
- Matteo Bassetti (ORCID: https://orcid.org/0000-0002-0145-9740)
- Laura Loughlin (ORCID: https://orcid.org/0000-0002-7367-3287)
- Riina Rautemaa‐Richardson (ORCID: https://orcid.org/0000-0002-1071-6040)
- Sevtap Arıkan-Akdağlı (ORCID: https://orcid.org/0000-0001-9807-6764)
- Julio García‐Rodríguez (ORCID: https://orcid.org/0000-0002-3771-8740)
- Murat Akova (ORCID: https://orcid.org/0000-0002-6904-9473)
- Stella Wolfgruber
- Jon Salmanton‐García (ORCID: https://orcid.org/0000-0002-6766-8297)
- Philipp Koehler (ORCID: https://orcid.org/0000-0002-7386-7495)
- Volkan Özenci (ORCID: https://orcid.org/0000-0002-8069-4027)
- Julio Dávila (ORCID: https://orcid.org/0000-0002-5185-2073)
- Martin Hoenigl (ORCID: https://orcid.org/0000-0002-1653-2824)
- Fanny Lanternier (ORCID: https://orcid.org/0000-0003-3800-4683)
- Nina Khanna (ORCID: https://orcid.org/0000-0002-2642-419X)
- Robert G. E. Krause (ORCID: https://orcid.org/0000-0003-1558-0397)
- Ola Blennow (ORCID: https://orcid.org/0000-0002-7167-7882)
- Oliver A. Cornely (ORCID: https://orcid.org/0000-0001-9599-3137)
- Thomas Longval (ORCID: https://orcid.org/0000-0002-0254-1519)
- Н Н Климко (ORCID: https://orcid.org/0000-0001-6095-7531)
- Matthias Egger (ORCID: https://orcid.org/0000-0002-7795-4406)
- Nick de Jonge (ORCID: https://orcid.org/0000-0002-9901-0887)
- Carolina García‐Vidal (ORCID: https://orcid.org/0000-0002-8915-0683)
- С. Н. Хостелиди (ORCID: https://orcid.org/0000-0001-5794-5396)
- Maiken Cavling Arendrup (ORCID: https://orcid.org/0000-0002-4747-0144)
- Juergen Prattes (ORCID: https://orcid.org/0000-0001-5751-9311)
- Sarah Sedik (ORCID: https://orcid.org/0009-0002-3070-2508)
- François Danion (ORCID: https://orcid.org/0000-0003-3907-0658)
- Alessandra Bandera (ORCID: https://orcid.org/0000-0003-1626-0328)
Institutions
- Statens Serum Institut (DK)
- University of Copenhagen (DK)
- Hôpital Necker-Enfants Malades (FR)
- Belfast Health and Social Care Trust (GB)
- Bursa Uludağ Üni̇versi̇tesi̇ (TR)
- Karolinska University Hospital (SE)
- Radboud University Nijmegen (NL)
- Inserm (FR)
- University of Cologne (DE)
- Medical University of Graz (AT)
- Université Paris Cité (FR)
- Manchester Academic Health Science Centre (GB)
- Hospital Universitario La Paz (ES)
- Instituto de Salud Carlos III (ES)
- University Hospitals of Leicester NHS Trust (GB)
- University Hospital of Basel (CH)
- Copenhagen University Hospital (DK)
- Radboud University Medical Center (NL)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Karolinska Institutet (SE)
- Ege University (TR)
- Public Health Wales (GB)
- Düsseldorf University Hospital (DE)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Manchester University NHS Foundation Trust (GB)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut de Recherche en Santé, Environnement et Travail (FR)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Hospital Clínic de Barcelona (ES)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Hôpitaux Universitaires de Strasbourg (FR)
- Ospedale Policlinico San Martino (IT)
- Wythenshawe Hospital (GB)
- Amsterdam University Medical Centers (NL)
- North-Western State Medical University named after I.I. Mechnikov (RU)
- Hospital Universitario Virgen del Rocío (ES)
- University Hospital Cologne (DE)
- Centre Hospitalier Universitaire de Rennes (FR)
- Centre Hospitalier de Versailles (FR)
- Hospital Nuestra Señora de Alarcos (ES)
- Heinrich Heine University Düsseldorf (DE)
- Université de Rennes (FR)
- Hacettepe University (TR)
- Université de Strasbourg (FR)
- Cardiff Metropolitan University (GB)
Publication Details
- Journal
- Journal of Infection
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.jinf.2025.106629
- Citations
- 2
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Institute for Health and Care Research
- Manchester Biomedical Research Centre