Molecular Characterization of Oncogenic Gene Fusions in a Large Real-World Cohort of Solid Tumors
This large, real-world pan-cancer study demonstrates that concurrent RNA- and DNA-based NGS significantly improves the detection of clinically actionable gene fusions compared with DNA-NGS alone. Our findings highlight the critical value of integrating RNA-NGS into routine molecular profiling to optimize the detection of driver gene fusions. Doing so may expand the population of patients eligible for matched targeted therapies or clinical trials, particularly in cancers with limited treatment options.
Authors
- Rotem Ben‐Shachar (ORCID: https://orcid.org/0000-0002-2717-0259)
- Adam J. Hockenberry (ORCID: https://orcid.org/0000-0001-9476-0104)
- Bradley Bowles (ORCID: https://orcid.org/0000-0001-9468-3284)
- Halla Nimeiri (ORCID: https://orcid.org/0000-0002-8760-6456)
- Lisa Gai (ORCID: https://orcid.org/0009-0001-0803-5246)
- Sandip Pravin Patel (ORCID: https://orcid.org/0000-0002-8387-4840)
- Justin Guinney (ORCID: https://orcid.org/0000-0003-1477-1888)
- Kyle A. Beauchamp (ORCID: https://orcid.org/0000-0001-6095-8788)
- Christine Chin (ORCID: https://orcid.org/0009-0003-4684-2924)
- Brittany Mineo (ORCID: https://orcid.org/0000-0001-9997-4232)
- Ben Ho Park (ORCID: https://orcid.org/0000-0001-8119-2291)
- Kate Sasser (ORCID: https://orcid.org/0009-0009-2804-1684)
Institutions
- Vanderbilt University (US)
- UC San Diego Health System (US)
- University of California San Diego (US)
- Tempus Labs (United States) (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0329
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00