Evaluation of post dental extraction wound healing and bone regeneration using topical combined application of osteogenic inducers -a randomized controlled trial

<h2>Abstract</h2><h3>Problem considered</h3> The bone loss is indeed substantial during the first three months following extraction and can result in both hard and soft tissue defects impacting the site's potential to regenerate with an acceptable amount of bone. The combination of Dexamethasone, Vitamin C and Beta-Sodium Glycerophosphate as an osteogenic inducer has the potential to trigger bone marrow derived stem cells to transform into osteoblasts, enhancing regeneration of bone. <h3>Methods</h3> 36 patients were divided equally into osteogenic group and non-osteogenic group who reported for extraction of mandibular third molar. In the osteogenic group an osteogenic inducer was placed in the extraction socket after the third molar was extracted, whereas in the non-osteogenic group no material was introduced. Patients were recalled at intervals of 1 day, 7 days, 1 and 3 months. Mann-Whitney's test and Generalized Estimating Equation (GEE) models was used. <h3>Results</h3> The osteogenic group showed significantly better wound healing as compared to the non-osteogenic group at the end of 7th day following extraction. Bone regeneration was assessed and the osteogenic group showed faster bone healing when compared to the non-osteogenic group in terms of presence of Lamina Dura, overall bone density and trabecular patterns when assessed after 3 months following extract ion. <h3>Conclusion</h3> Osteogenic inducer used as a graft material showed improved wound and bone healing when placed in the third molar extraction sockets with the added benefits of no additional donor site requirement, reduced postoperative complications and is not technique sensitive.