Convergence of genetic variants in MCR-1 and O-antigen conferring polymyxin resistance and fitness cost
Collectively, the co-occurrence of plasmid-borne mcr-1 and bla<sub>NDM-5</sub> was determined, with genetic variations in LPS biosynthesis genes potentially contributing to a synergistic change in bacterial surface charge and corresponding electrostatics to polymyxin.
Authors
- Aiping Zhou (ORCID: https://orcid.org/0000-0002-6617-6653)
- Na Lv (ORCID: https://orcid.org/0000-0001-8522-0560)
- Guoping Wu (ORCID: https://orcid.org/0000-0001-7797-7627)
- Yuting Yang (ORCID: https://orcid.org/0000-0002-1064-688X)
- Dongjiang Wang
- Jun Li
- Jinfeng Lü (ORCID: https://orcid.org/0009-0005-5256-8081)
- Shuang Wan
Institutions
- Shanghai East Hospital (CN)
- Jiangxi Agricultural University (CN)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.jgar.2025.10.005
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00