Cytotoxic, anti-inflammatory, antioxidant, and anti-glyoxalase-I evaluation of chelating substances: In silico and in vitro study
Further assessment of molecular action mechanisms and structural betterments/enhancements and/or derivatization of promising potent agents with antiglyoxylase - antiinflammation duality along with differential cytotoxicity and reductive capacities are advisably warranted with appropriately matched downstream in vivo validation modalities.
Authors
- Aref Zayed (ORCID: https://orcid.org/0000-0003-0211-1866)
- Violet Kasabri (ORCID: https://orcid.org/0000-0003-1927-0193)
- Belal O. Al‐Najjar (ORCID: https://orcid.org/0000-0001-6811-1792)
- Qosay Al‐Balas
- Yusuf Al‐Hiari
- Rema Alkhateeb
- Mohammed Al-Akeedi (ORCID: https://orcid.org/0000-0002-3842-7419)
- MohammedBashar Al-Qazzan (ORCID: https://orcid.org/0000-0002-5723-6247)
Institutions
- Al-Ahliyya Amman University (JO)
- University of Jordan (JO)
- Jordan University of Science and Technology (JO)
- Alrafidain University College (IQ)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1371/journal.pone.0333405
- Citations
- 2
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 1.61