Oncologic and physiologic predictors of mortality after intensive care unit admission in patients with lung cancer
Lung cancer patients admitted to ICU experience high short-term mortality, with outcomes shaped by both oncologic status and the severity of acute illness. A dual-model approach suggests a risk hierarchy: Cancer-specific factors inform baseline mortality risk with an ICU admission, but age and physiologic derangement are the dominant drivers of survival once critical illness develops. These findings support dynamic, multidisciplinary prognostication and underscore the need to integrate oncology and critical care expertise in ICU decision-making.
Authors
- Konstantinos Leventakos (ORCID: https://orcid.org/0000-0001-9784-8603)
- Julian R. Molina (ORCID: https://orcid.org/0000-0002-9962-4635)
- Adil Ramzan (ORCID: https://orcid.org/0000-0001-8683-9330)
- Hemang Yadav (ORCID: https://orcid.org/0000-0002-1889-2524)
- Aaron S. Mansfield (ORCID: https://orcid.org/0000-0002-9483-6903)
- Cameron G. Gmehlin (ORCID: https://orcid.org/0000-0003-0750-4781)
- Kaushal Parikh (ORCID: https://orcid.org/0000-0001-6759-9351)
- Regina M. Koch (ORCID: https://orcid.org/0000-0001-6618-6862)
Institutions
- Mayo Clinic (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Annals of the American Thoracic Society
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1513/annalsats.202506-672oc
- Citations
- 1
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 1.22