Efficacy and safety of pre-emptive tapentadol on pain control in total knee arthroplasty: A randomized, double-blind, placebo-controlled trial

A preemptive single dose of 100 mg oral tapentadol is safe, effective, and significantly reduces postoperative pain and rescue analgesic requirements in TKA patients. This approach may reduce opioid dependence and support enhanced recovery protocols.

Authors

Sujit Kumar Tripathy (ORCID: https://orcid.org/0000-0003-0179-9910)
Samiksha Bhattacharjee (ORCID: https://orcid.org/0000-0002-2951-8861)
Debasish Hota (ORCID: https://orcid.org/0000-0002-7339-1773)
Sunil Doki (ORCID: https://orcid.org/0000-0002-2448-7250)
Anand Srinivasan

Institutions

All India Institute of Medical Sciences Bhubaneswar (IN)

Publication Details

Journal: World Journal of Orthopedics
Published: 2025-10-16
DOI: https://doi.org/10.5312/wjo.v16.i10.110233
Primary Topic: Anesthesia and Pain Management
Type: article
Field-Weighted Citation Impact: 0.00

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article

Efficacy and safety of pre-emptive tapentadol on pain control in total knee arthroplasty: A randomized, double-blind, placebo-controlled trial

Sujit Kumar Tripathy, Samiksha Bhattacharjee, Debasish Hota, Sunil Doki et al.

Oct 16, 2025

World Journal of Orthopedics

Anesthesia and Pain Management

article

Efficacy and safety of pre-emptive tapentadol on pain control in total knee arthroplasty: A randomized, double-blind, placebo-controlled trial

Sujit Kumar Tripathy, Samiksha Bhattacharjee, Debasish Hota, Sunil Doki, Anand Srinivasan

October 16, 2025article en

Abstract

A preemptive single dose of 100 mg oral tapentadol is safe, effective, and significantly reduces postoperative pain and rescue analgesic requirements in TKA patients. This approach may reduce opioid dependence and support enhanced recovery protocols.

World Journal of OrthopedicsVol. 16(10)

All India Institute of Medical Sciences Bhubaneswar (IN)

Openalex Percentile: Top 54%

Anesthesia and Pain Management

DOI Open Access PDF OpenAlex

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