IMGT® at scale: FAIR, dynamic, and automated tools for immune locus analysis
IMGT®, the international ImMunoGeneTics information system®, has advanced its comprehensive platform for the analysis of immunoglobulin (IG) and T-cell receptor (TR) genes through the development of new automated and scalable tools. This article presents major updates aligned with IMGT's three axes of research. Axis I introduces dynamic resources such as IMGT/GeneTables, IMGT/AssemblyComparison, IMGT/CDRLengths, IMGT/MultiGenomeViewer, enabling real-time access to annotated genomic data, and IMGT/StatAssembly to assess quality of IG/TR loci in assemblies. Axis II enhances repertoire analysis with a redesigned IMGT/GeneFrequency tool and new customization features in IMGT/V-QUEST, supporting flexible exploration of IG and TR gene expression. Axis III improves the accurate prediction of peptide-MHC thanks to IMGT/RobustpMHC. Additionally, the IMGT knowledge graph and its therapeutic extension, IMGT/mAb-KG, provide semantically structured access to >100 million immunogenetic triplets, integrating IMGT databases and linking IMGT content to external biomedical resources. These developments promote standardization, interoperability, and integrative analysis across immunogenetics and clinical applications, reinforcing IMGT's (accessible at https://www.imgt.org) role as a core reference in the era of FAIR data and personalized medicine.
Authors
- Géraldine Folch (ORCID: https://orcid.org/0000-0002-5677-5193)
- Véronique Giudicelli (ORCID: https://orcid.org/0000-0002-2258-468X)
- Taciana Manso (ORCID: https://orcid.org/0000-0001-9787-0640)
- Patrice Duroux (ORCID: https://orcid.org/0000-0001-8935-7900)
- Gaoussou Sanou (ORCID: https://orcid.org/0000-0003-2204-2466)
- Anjana Kushwaha (ORCID: https://orcid.org/0009-0002-9046-9584)
- Chahrazed Debbagh (ORCID: https://orcid.org/0000-0002-4594-617X)
- Maria Georga (ORCID: https://orcid.org/0000-0002-3969-7437)
- Joumana Jabado-Michaloud (ORCID: https://orcid.org/0000-0003-4291-2027)
- Ariadni Papadaki (ORCID: https://orcid.org/0000-0001-6497-032X)
- Shamsa Batool
- Myriam Croze (ORCID: https://orcid.org/0000-0003-2164-1395)
- Milad Eidi (ORCID: https://orcid.org/0000-0001-5582-4435)
- Nika Abdollahi (ORCID: https://orcid.org/0000-0003-2618-4760)
- Sofia Kossida (ORCID: https://orcid.org/0000-0003-2482-0022)
- Alexandre Vaillant
- François Grand
- Guilhem Zeitoun (ORCID: https://orcid.org/0009-0002-6742-1646)
- Ifigeneia Sideri (ORCID: https://orcid.org/0000-0001-9986-7904)
- Turkan Samadova
Institutions
- Centre National de la Recherche Scientifique (FR)
- Institut Universitaire de France (FR)
- Institut de Génétique Humaine (FR)
Publication Details
- Journal
- Nucleic Acids Research
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1093/nar/gkaf1024
- Citations
- 4
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Infrastructures en Biologie Santé et Agronomie
- Institut Français de Bioinformatique
- Agence Nationale de la Recherche
- Centre National de la Recherche Scientifique
- Institut Universitaire de France
- Hospices Civils de Lyon
- Université Claude Bernard Lyon 1
- Université de Montpellier
- Grand Équipement National De Calcul Intensif