Primed human pluripotent stem cell-derived blastocyst-like cell aggregates with partial lineage specification
This work introduces a more accessible platform for generating human blastocyst-like cell aggregates from primed hPSCs, broadening their utility for investigating early development events. Insights gained from blastocyst-like cell aggregates have the potential to advance the modelling of early-onset diseases, drive innovations in regenerative therapies, and contribute to the development of assisted reproductive technologies.
Authors
- Shiho Terada (ORCID: https://orcid.org/0000-0002-9901-5012)
- Xiaopeng Wen (ORCID: https://orcid.org/0000-0002-9423-5171)
- Kei Saito (ORCID: https://orcid.org/0000-0002-5726-8775)
- Satoshi Imamura (ORCID: https://orcid.org/0000-0002-7992-1712)
- K Sawada
- Kaori Mutsuda-Zapater
- Ken‐ichiro Kamei (ORCID: https://orcid.org/0000-0003-2948-3264)
Institutions
- Shenyang Pharmaceutical University (CN)
- New York University Abu Dhabi (AE)
- Kyoto University (JP)
- New York University (US)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.reth.2025.10.007
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00