Mathematical Modeling Quantifies “Just-Right” APC Inactivation for Colorectal Cancer Initiation
Mathematical modeling of tumor development with different APC genotypes substantiates the "just-right" APC inactivation model and suggests alterations in secondary WNT regulators enhance WNT activity in colorectal cancers with suboptimal APC genotypes. This article is part of a special series: Driving Cancer Discoveries with Computational Research, Data Science, and Machine Learning/AI .
Authors
- Michael D. Nicholson (ORCID: https://orcid.org/0000-0003-2813-8979)
- Ignacio Soriano (ORCID: https://orcid.org/0000-0002-7928-3511)
- S. Thorn (ORCID: https://orcid.org/0000-0002-9962-9356)
- Ian Tomlinson (ORCID: https://orcid.org/0000-0003-3037-1470)
- Tibor Antal (ORCID: https://orcid.org/0000-0002-9640-8400)
- Nathalie Feeley (ORCID: https://orcid.org/0000-0003-0124-6398)
- Meritxell Brunet Guasch
Institutions
- Edinburgh Cancer Research (GB)
- University of Oxford (GB)
- Maxwell Institute for Mathematical Sciences (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0445
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Heriot-Watt University
- Wellcome Trust
- Cancer Research UK
- Engineering and Physical Sciences Research Council