Prognostic significance of CD8+ T cell Spatial Biomarkers in ER+ and ER− breast cancer: A retrospective cohort study
Spatial characteristics described by proximity and consistency are frequently associated with recurrence irrespective of ER status. The prognostic significance of proximity in ER+ breast cancer implies that spatial parameters may identify individuals who would benefit from immune therapy; up to 75% of breast cancers experience T cell proximity suggestive of immune susceptibility.
Authors
- Katherine A. Hoadley (ORCID: https://orcid.org/0000-0002-1216-477X)
- Gabriela De la Cruz (ORCID: https://orcid.org/0000-0002-6019-5853)
- James Stephen Marron (ORCID: https://orcid.org/0000-0003-2000-1476)
- Charles M. Perou (ORCID: https://orcid.org/0000-0001-9827-2247)
- Melissa A. Troester (ORCID: https://orcid.org/0000-0001-9506-6624)
- Joel Saltz (ORCID: https://orcid.org/0000-0002-3451-2165)
- Xiaohua Gao (ORCID: https://orcid.org/0000-0003-4308-6126)
- Qichen Wang
- Didong Li (ORCID: https://orcid.org/0000-0001-9146-705X)
- A. Walker
Institutions
- University of North Carolina at Chapel Hill (US)
- Stony Brook University (US)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1371/journal.pmed.1004647
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05