Metabolomics and metagenomics in mice reveal the role of the gut microbiota in tryptophan metabolism

Tryptophan metabolism plays a key role in host-microbiota interactions, producing a wide array of bioactive metabolites. However, our understanding of the interactions between tryptophan metabolites and the gut microbiota is still limited. Using targeted quantitative metabolomics and metagenomics in mice across various compartments, we showed that the cecal microbiota massively impacts tryptophan metabolism both in the gut and systemically. Grouping bacterial taxa in co-abundance guilds better reflected the links between gut microbes and tryptophan metabolites than single taxa taken individually and suggested the involvement of complex microbial interactions in tryptophan metabolism regulation. Finally, analyzing functional data, we shed light on the potential links between tryptophan metabolism and bacterial enzymes or metabolic pathways.

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Publication Details

Journal
iScience
Published
2025-10-15
DOI
https://doi.org/10.1016/j.isci.2025.113751
Citations
1
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.81
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Metabolomics and metagenomics in mice reveal the role of the gut microbiota in tryptophan metabolism

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Metabolomics and metagenomics in mice reveal the role of the gut microbiota in tryptophan metabolism

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article en
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Abstract

Tryptophan metabolism plays a key role in host-microbiota interactions, producing a wide array of bioactive metabolites. However, our understanding of the interactions between tryptophan metabolites and the gut microbiota is still limited. Using targeted quantitative metabolomics and metagenomics in mice across various compartments, we showed that the cecal microbiota massively impacts tryptophan metabolism both in the gut and systemically. Grouping bacterial taxa in co-abundance guilds better reflected the links between gut microbes and tryptophan metabolites than single taxa taken individually and suggested the involvement of complex microbial interactions in tryptophan metabolism regulation. Finally, analyzing functional data, we shed light on the potential links between tryptophan metabolism and bacterial enzymes or metabolic pathways.

iScienceVol. 28(11)
Université de Tours (FR), Inserm (FR), University of Trento (IT), Université Paris-Saclay (FR), Microbiologie de l’alimentation au service de la santé (FR), Sorbonne Université (FR), Centre Hospitalier Universitaire de Tours (FR), Assistance Publique – Hôpitaux de Paris (FR), Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine (FR), Centre de Recherche Saint-Antoine (FR), European Institute of Oncology (IT)
Openalex Percentile: Top 22%
Gut microbiota and health
0.81
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