LINC01871 is exclusively expressed in T and NK cells and is highly induced upon CD4+ T cell activation
Long intergenic noncoding RNAs (lincRNAs) regulate biological processes in health and disease. Recent findings highlight the importance of lincRNAs in regulating T cell development and function. Here, we identified a lincRNA, LINC01871, which is highly induced upon CD4<sup>+</sup> T cell activation and is predominantly located in the cytoplasm. The anti-inflammatory cytokine TGF-β was found to suppress its expression. Silencing LINC01871 led to a modest decrease in IL-2 secretion. Notably, LINC01871 expression was highly specific to NK cells and T cells in several cross-tissue single cell RNA-seq atlases. These data suggest that LINC01871 is specifically expressed in T and NK cells and may contribute to T cell-mediated immunity in humans.
Authors
- Omid Rasool (ORCID: https://orcid.org/0000-0002-1286-4725)
- Miro Viitala (ORCID: https://orcid.org/0000-0002-0951-0168)
- Olof Rundquist (ORCID: https://orcid.org/0000-0002-1424-3658)
- Riitta Lahesmaa (ORCID: https://orcid.org/0000-0002-4782-9567)
- Sanjeev Galande (ORCID: https://orcid.org/0000-0002-7251-1905)
- Tommi Välikangas (ORCID: https://orcid.org/0000-0002-6046-1920)
- Antti Hurme (ORCID: https://orcid.org/0000-0001-6764-0262)
- Inna Starskaia (ORCID: https://orcid.org/0000-0003-4349-439X)
- Venla Kumpulainen (ORCID: https://orcid.org/0000-0003-3375-5445)
- Laura L. Elo (ORCID: https://orcid.org/0000-0001-5648-4532)
- Sini Junttila (ORCID: https://orcid.org/0000-0003-3754-5584)
- António G. G. Sousa (ORCID: https://orcid.org/0000-0003-4779-6459)
- Ankitha Shetty (ORCID: https://orcid.org/0000-0002-6940-2580)
- Kedar Batkulwar (ORCID: https://orcid.org/0000-0002-4115-7958)
- Ubaid Ullah Kalim
- Aarati R. Ranade
- Sakari Kosola
Institutions
- Åbo Akademi University (FI)
- University of Turku (FI)
- Turku Centre for Computer Science (FI)
Publication Details
- Journal
- iScience
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.isci.2025.113779
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00