Ebstein-Bar Virus (EBV)-Positive diffuse large B-cell vitreoretinal lymphoma: Two cases without overt immunocompromise and review of the literature

Vitreoretinal lymphoma (VRL) remains a challenging diagnosis. EBV-positive LBCL-VR is an exceedingly rare entity with distinctive demographic and immunologic features. In addition to overt immunocompromise, immunosenescence may also be associated with EBV-positive LBCL-VR. EBV status should be evaluated in all cases of LBCL-VR, especially in LBCL without mutations in <i>MYD88</i> and/or <i>CD79a</i>.