Circulating exosomes in sepsis induce PD-1 expression in macrophages and promote Th17 differentiation
Sepsis-derived exosomes induced PD-1 expression in macrophages and promoted Th17 differentiation, revealing a novel mechanism of immune dysregulation in sepsis. These findings provide new insights into immune dysregulation in sepsis pathophysiology.
Authors
- Tsu‐Hsiang Lu
- Ming‐Yu Yang (ORCID: https://orcid.org/0000-0002-6841-5478)
- Chia‐Wen Tsai (ORCID: https://orcid.org/0000-0002-6698-7747)
- Shao‐Chun Wu (ORCID: https://orcid.org/0000-0002-0984-6921)
- Cheng‐Shyuan Rau
- Ching‐Hua Hsieh (ORCID: https://orcid.org/0000-0002-0945-2746)
- Chia-Wei Lin
- Yi-Chan Wu (ORCID: https://orcid.org/0000-0001-7221-7151)
Institutions
- Chang Gung University (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1097/js9.0000000000003651
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00