Fentanyl Disrupts Vagal Control of Airway Tone to Induce Transient Obstruction
Fentanyl disrupts respiratory-autonomic integration by enhancing parasympathetic vagal drive, producing a central, opioid receptor-mediated mechanism of airway constriction. Targeting vagal pathways may therefore represent a promising adjunctive strategy for improving airway patency and ventilatory recovery during opioid overdose reversal.
Authors
- Richard C. Parks (ORCID: https://orcid.org/0000-0001-9305-0450)
- Michelle Fog Andersen
- Nicholas J. Burgraff (ORCID: https://orcid.org/0000-0001-7986-4247)
- Mackenna L. Hatfield
Institutions
- University of Wisconsin System (US)
- University of Wisconsin–Madison (US)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1111/apha.70119
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health