Real-life Use of Cabozantinib in Front-line therapy for Metastatic Renal Cell Carcinoma: The CabFRONT Study (Meet-URO 24)
We looked at outcomes for patients with metastatic kidney cancer treated with an inhibitor called cabozantinib in a large European population. We found that cabozantinib is active and safe, and that changes in the dose or treatment schedule because of side effects do not affect outcomes. Cabozantinib could be an option for patients who cannot receive immunotherapy for metastatic disease.
Authors
- Luca Lalli (ORCID: https://orcid.org/0000-0002-4472-628X)
- Marilena Di Napoli (ORCID: https://orcid.org/0000-0003-4516-7341)
- Marco Stellato
- Matteo Santoni (ORCID: https://orcid.org/0000-0001-7340-6173)
- Luca Galli (ORCID: https://orcid.org/0000-0001-6008-0266)
- Marco Maruzzo (ORCID: https://orcid.org/0000-0002-6256-9249)
- Elisa Zanardi (ORCID: https://orcid.org/0000-0002-3252-4226)
- Maria Cossu Rocca (ORCID: https://orcid.org/0000-0002-5780-3774)
- Giandomenico Roviello (ORCID: https://orcid.org/0000-0001-5504-8237)
- Vincenza Conteduca (ORCID: https://orcid.org/0000-0002-6921-714X)
- Elena Verzoni (ORCID: https://orcid.org/0000-0001-9756-6112)
- Giuseppe Procopio (ORCID: https://orcid.org/0000-0002-2498-402X)
- Lorena Incorvaia (ORCID: https://orcid.org/0000-0002-1199-7286)
- Enrico Bronte
- Paolo Andrea Zucali (ORCID: https://orcid.org/0000-0002-2274-1702)
- Ugo De Giorgi (ORCID: https://orcid.org/0000-0001-7520-2908)
- Brigida Anna Maiorano (ORCID: https://orcid.org/0000-0001-5423-3158)
- Mariella Sorarů (ORCID: https://orcid.org/0000-0001-5198-7755)
- Pierangela Sepe (ORCID: https://orcid.org/0000-0002-0645-7293)
- Alessia Mennitto (ORCID: https://orcid.org/0000-0002-3665-3295)
Institutions
- University of Foggia (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- AOL (United States) (US)
- Humanitas University (IT)
- Casa Sollievo della Sofferenza (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Ospedale Vincenzo Cervello (IT)
- Istituto Oncologico Veneto (IT)
- Azienda Ospedaliero Universitaria Maggiore della Carita (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Azienda Ospedaliera Ospedale Maggiore (IT)
- Ospedale Policlinico San Martino (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
- University of Florence (IT)
- University of Macerata (IT)
- European Institute of Oncology (IT)
- University of Palermo (IT)
Publication Details
- Journal
- European Urology Open Science
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.euros.2025.09.014
- Citations
- 1
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52