Halogen Atom Transfer Enabled Radical Fluoroalkyl‐Thiolation of Unactivated Alkenes
A halogen atom transfer‐enabled radical fluoroalkyl‐thiolation of unactivated alkenes is developed employing fluoroalkyl iodides, TMEDA‐ligated zinc thiolates. Notably, the aryldiazonium salts are utilized as the promoter in the three‐component reaction, providing a powerful tool for simultaneous construction of CRf and CS bonds across the CC bond. Moreover, direct thiolation of fluoroalkyl iodides without alkene gives the two‐component reaction products. Mechanistic studies support that the interaction between diazonium salt and zinc thiolate plays a crucial role in the transformations.
Authors
- Ying Bai (ORCID: https://orcid.org/0000-0001-5630-5565)
- Xinxin Shao (ORCID: https://orcid.org/0000-0001-5526-8344)
- Aman Ullah (ORCID: https://orcid.org/0000-0003-1801-0162)
- Shao‐Fei Ni (ORCID: https://orcid.org/0000-0001-9860-2138)
- Yanchuang Zhao
- Y. Xie (ORCID: https://orcid.org/0000-0001-5012-4069)
Institutions
- Hangzhou Normal University (CN)
- Shantou University (CN)
- Ji Hua Laboratory (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1002/adsc.70162
- Citations
- 1
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.79
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province
- Natural Science Foundation of Zhejiang Province