Treatment-Resistant Atopic Dermatitis in Adulthood: A Case Report

Atopic dermatitis (AD) is a chronic and relapsing skin condition that often begins in childhood but can persist or worsen into adulthood, significantly impacting quality of life. We present the case of a 41-year-old woman with long-standing, treatment-resistant AD, unresponsive to various systemic therapies including corticosteroids, methotrexate, thalidomide, and cyclosporine. Despite some control with methotrexate, she experienced frequent flares and side effects. This report highlights the clinical challenges and therapeutic considerations in managing chronic, treatment-resistant AD. It also shows the potential of targeted biologic therapies as more effective and better-tolerated alternatives. Early recognition of treatment resistance is crucial to improving patient outcomes.