Midlife ICAM-1 levels may predict cardiovascular disease and cognitive decline in latelife: Insights from the HeartSCORE study
In a community cohort of adults, midlife levels of three inflammatory markers (hs-CRP, IL-6, and ICAM-1) were predictive of late life ASCVD; however, only ICAM-1 was identified as a dual marker for ASCVD and cognitive impairment. The role of ICAM-1 as a prognostic marker for adverse cardiovascular and cognitive health should be explored in future studies.
Authors
- Ann D. Cohen (ORCID: https://orcid.org/0000-0001-7395-9624)
- Ian Pollack
- Steven E. Reís (ORCID: https://orcid.org/0000-0001-8023-0102)
- Anum Saeed (ORCID: https://orcid.org/0000-0003-1783-678X)
- Yue‐Fang Chang (ORCID: https://orcid.org/0000-0003-0080-4597)
- Kevin E. Kip (ORCID: https://orcid.org/0000-0002-6401-0051)
- Justin Swanson (ORCID: https://orcid.org/0000-0001-6304-8069)
- Khaled Abdoun
- Oscar L. Lopez
Institutions
- University of Pittsburgh (US)
- University of South Florida (US)
- UPMC Health System (US)
Publication Details
- Journal
- Atherosclerosis Plus
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.athplu.2025.10.001
- Citations
- 1
- Primary Topic
- Cardiovascular Health and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.39