Metabolic syndrome worsens sarcopenia and reduces nutritional therapy benefits in advanced gastric cancer
The integration of genetic and clinical findings shows that MetS components causally contribute to sarcopenia pathogenesis, and that the composite MetS phenotype confers nutritional therapy resistance. This establishes MetS's dual role as a driver of disease and a modifier of treatment efficacy.
Authors
- Vincent Kam Wai Wong (ORCID: https://orcid.org/0000-0002-2951-8108)
- Xuchen Zhang (ORCID: https://orcid.org/0000-0002-1484-4672)
- Wang Yao (ORCID: https://orcid.org/0000-0003-2883-4528)
- Yuxin Feng
- Lu Xu
- Ying Feng
Institutions
- Macau University of Science and Technology (MO)
- Chinese Academy of Sciences (CN)
- University of Macau (MO)
- Zhejiang Cancer Hospital (CN)
- Lishui Central Hospital (CN)
- Suzhou Municipal Hospital (CN)
- Hangzhou Cancer Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fnut.2025.1615376
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00