Gut microbiota-mediated berberine metabolism ameliorates cholestatic liver disease by suppressing 5-hydroxytryptamine production
BBR is transformed by gut microbiota to ameliorate CLD via inhibiting 5-HT, suggesting potential novel strategies for further clinical use.
Authors
- Dianji Tu
- Lu Cheng (ORCID: https://orcid.org/0000-0002-0810-6550)
- Yusong Ge (ORCID: https://orcid.org/0000-0001-7889-1462)
- Bo Tang (ORCID: https://orcid.org/0000-0002-1369-9645)
- Jiyin Zhou (ORCID: https://orcid.org/0000-0003-4313-4191)
- Hua Diao
- Z. L. Hou (ORCID: https://orcid.org/0009-0006-7189-367X)
- Jincheng Jian
- Hongfei Jiang (ORCID: https://orcid.org/0000-0001-5869-5253)
- Yingjie Wang (ORCID: https://orcid.org/0000-0003-1005-7900)
- Junfeng Guo
- Xin Li (ORCID: https://orcid.org/0000-0001-7630-0163)
- Shiming Yang (ORCID: https://orcid.org/0000-0002-0000-4795)
- Qiao Chen (ORCID: https://orcid.org/0000-0003-2976-5261)
- Lulu Cheng (ORCID: https://orcid.org/0000-0002-4984-1279)
- Xiaojie Feng
- Lei Ran (ORCID: https://orcid.org/0000-0003-3925-4801)
- Yuanyuan Lei (ORCID: https://orcid.org/0000-0001-9900-2150)
- Jianchun Zhou
- Zhengguo Xu
- Yunxuan Feng
- Yuanyuan Zhou (ORCID: https://orcid.org/0000-0003-3534-2273)
Institutions
- Army Medical University (CN)
- Xinqiao Hospital (CN)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3350/cmh.2025.0577
- Citations
- 3
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- National Natural Science Foundation of China