Metabolomic profiling and stable isotope tracing of human schwannomas: A novel perspective on tumor biology and radiation response
Schwannomas have distinct metabolic signatures compared to the Schwann cells from which they originate. Schwannoma xenograft metabolism is surprisingly robust to radiotherapy, and xenografts readily incorporate glutamine into the TCA cycle, urea cycle, and pyrimidine synthesis.
Authors
- David Ronan Raleigh (ORCID: https://orcid.org/0000-0001-9299-8864)
- Hashim Syed (ORCID: https://orcid.org/0009-0005-5284-9895)
- Adam J. Rauckhorst (ORCID: https://orcid.org/0000-0002-4101-0075)
- Mark C. Dougherty (ORCID: https://orcid.org/0000-0003-3247-0261)
- Marlan R. Hansen (ORCID: https://orcid.org/0000-0002-6884-4897)
- Eric B. Taylor (ORCID: https://orcid.org/0000-0003-4549-6567)
- Siyuan Liu (ORCID: https://orcid.org/0000-0003-1042-0191)
- Linjing Xu
Institutions
- University of Iowa (US)
- Johns Hopkins University (US)
- University of California, San Francisco (US)
- Florida International University (US)
- Johns Hopkins Medicine (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1093/noajnl/vdaf223
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health