Case report: Adolescent breast hypertrophy with a tendency toward phyllodes tumor formation: first reported case in China

Adolescent breast hypertrophy is a rare and persistent condition that affects peripubertal females both physiologically and psychologically. We present a case of a 14-year-old patient with bilateral giant breast enlargement who underwent a successful reduction mammoplasty of 16.5% Body Weight. The right breast exhibited focal interstitial proliferation myofibroblasts, suggesting a potential risk for phyllodes tumor development. This finding represents a novel histopathological association, unreported in the literature and first documented in China.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-10-15
DOI
https://doi.org/10.3389/fonc.2025.1652446
Primary Topic
Breast Lesions and Carcinomas
Type
article
Field-Weighted Citation Impact
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article

Case report: Adolescent breast hypertrophy with a tendency toward phyllodes tumor formation: first reported case in China

Yange Zhang, Ruiheng Liao, Yang Xiao, Yu‐Ting Chang et al.
Frontiers in Oncology
Breast Lesions and Carcinomas
article

Case report: Adolescent breast hypertrophy with a tendency toward phyllodes tumor formation: first reported case in China

Yange Zhang, Ruiheng Liao, Yang Xiao, Yu‐Ting Chang, Zhang Zhang
article en

Abstract

Adolescent breast hypertrophy is a rare and persistent condition that affects peripubertal females both physiologically and psychologically. We present a case of a 14-year-old patient with bilateral giant breast enlargement who underwent a successful reduction mammoplasty of 16.5% Body Weight. The right breast exhibited focal interstitial proliferation myofibroblasts, suggesting a potential risk for phyllodes tumor development. This finding represents a novel histopathological association, unreported in the literature and first documented in China.

Frontiers in OncologyVol. 15
Sichuan University (CN), West China Hospital of Sichuan University (CN)
Openalex Percentile: Top 59%
Breast Lesions and Carcinomas
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