Characterising microstructural retinal changes in children with inherited retinal dystrophies – a retrospective observational cross-sectional study
Our findings suggest retinal remodelling takes place in childhood-onset IRDs. Clinical trials in IRDs should consider remodelling when evaluating treatment effects. Future studies on the longitudinal natural history of retinal microstructural changes in childhood IRDs are required to address the impact of factors including IRD type, sex, age and disease duration.
Authors
- Jonathan B. Ruddle (ORCID: https://orcid.org/0000-0003-3879-2704)
- Marianne Piano (ORCID: https://orcid.org/0000-0003-0714-6339)
- Jasleen K. Jolly (ORCID: https://orcid.org/0000-0001-9878-4621)
- Lauren N. Ayton (ORCID: https://orcid.org/0000-0001-9907-084X)
- Eve J. Higginbotham (ORCID: https://orcid.org/0000-0003-0537-5410)
- Jonathon Holland (ORCID: https://orcid.org/0000-0001-6239-4306)
- Brent M Rodda
Institutions
- Royal Children's Hospital (AU)
- The University of Melbourne (AU)
- University of Cambridge (GB)
- Australian College of Optometry (AU)
- Centre for Eye Research Australia (AU)
- Museum of Contemporary Art San Diego (US)
Publication Details
- Journal
- Graefe s Archive for Clinical and Experimental Ophthalmology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1007/s00417-025-06983-7
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00