Targeting Epac1 to protect the blood brain barrier from inflammation-induced dysfunction: Evidence from an in vitro model
These findings identify Epac1 as a novel modulator of BBB integrity during inflammation and support the therapeutic potential of selectively targeting cAMP signaling pathways to preserve BBB function in neurodegenerative diseases associated with neuroinflammation.
Authors
- Aitor Picos (ORCID: https://orcid.org/0000-0002-2968-5897)
- Dolores Viña (ORCID: https://orcid.org/0000-0001-5777-1955)
- Nuria Seoane (ORCID: https://orcid.org/0009-0001-3944-9492)
- Manuel Campos‐Toimil (ORCID: https://orcid.org/0000-0003-3674-3749)
Institutions
- Universidade de Santiago de Compostela (ES)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.lfs.2025.124022
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00