The significance of m6A-circFOXK2 in CD4+T cells from patients with rheumatoid arthritis and circFOXK2 correlates with Th17 % and autophagy
We indicated a notable decrease in the m6A-methylated level of circFOXK2 in CD4<sup>+</sup>T cells from human RA, indicating a potential role of hypomethylated circFOXK2 in CD4<sup>+</sup>T cells function and RA pathogenesis. This may show valuable insight into the ALKBH5/m6A-circFOXK2/miRNA interaction network and the mechanism of RA.
Authors
- Peng Fu (ORCID: https://orcid.org/0000-0003-2982-6300)
- Qiuyun Xiao
- Ming‐Ying Lan (ORCID: https://orcid.org/0000-0001-5565-9580)
- Shiqian Wang (ORCID: https://orcid.org/0009-0007-0007-5650)
- Biqi Fu (ORCID: https://orcid.org/0000-0001-8960-473X)
- Zhiwei Wu (ORCID: https://orcid.org/0000-0002-0672-948X)
- Qing Luo (ORCID: https://orcid.org/0000-0001-7559-5174)
- Junming Li (ORCID: https://orcid.org/0000-0003-1409-3634)
- Zikun Huang (ORCID: https://orcid.org/0000-0001-8671-6074)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
Publication Details
- Journal
- Journal of Translational Autoimmunity
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.jtauto.2025.100326
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81