Circulating biomarkers predict platelet recovery in adult dengue patients with thrombocytopenia receiving prophylactic platelet transfusion
Our findings highlight that individual differences in immune response exist regardless of transfusion, underscoring the potential for personalized treatment in managing hospitalized adult dengue patients. The identified immune signature suggests that more targeted therapies may benefit patients unlikely to respond to platelet transfusion.
Authors
- Tun-Linn Thein (ORCID: https://orcid.org/0000-0002-5254-032X)
- Lisa F. P. Ng (ORCID: https://orcid.org/0000-0003-4071-5222)
- Liang Hui Loo
- Bernett Teck Kwong Lee (ORCID: https://orcid.org/0000-0002-2709-1972)
- David Chien Lye (ORCID: https://orcid.org/0000-0003-0324-0205)
- Siew‐Wai Fong (ORCID: https://orcid.org/0000-0002-5326-489X)
- Laurent Rénia (ORCID: https://orcid.org/0000-0003-0349-1557)
- Siti Naqiah Amrun (ORCID: https://orcid.org/0000-0001-6939-8123)
- Po Ying Chia (ORCID: https://orcid.org/0000-0002-8797-9527)
- Yee-Sin Leo
- Anna X. Y. Loo
Institutions
- Agency for Science, Technology and Research (SG)
- Nanyang Technological University (SG)
- Tan Tock Seng Hospital (SG)
- National University Health System (SG)
- National Centre for Infectious Diseases (SG)
- A*STAR Graduate Academy (SG)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.ijid.2025.108133
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agency for Science, Technology and Research
- Medical Research Council
- National Medical Research Council
- Biomedical Research Council