In vitro anti-glucocorticoid osteoporosis effect of Serfurosterone A and its intestinal absorption characteristics
SSA mitigates DEX-induced osteogenic inhibition and exhibits favorable intestinal absorption, suggesting its potential as a promising oral candidate for glucocorticoid-induced osteoporosis (GIOP). These results underscore the therapeutic promise of Achyranthes-derived phytosterols for future drug development.
Authors
- Jinhao Xue
- Jiaojiao Dong
- Liu Yang
- Xiaojuan Zhang (ORCID: https://orcid.org/0009-0005-1579-6851)
- Yanping Sun
- Lin Yang (ORCID: https://orcid.org/0009-0007-5352-3058)
- Shiwen Gao
Institutions
- Heilongjiang University of Chinese Medicine (CN)
Publication Details
- Journal
- Xenobiotica
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1080/00498254.2025.2574899
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00