Integrated single-cell and bulk RNA sequencing analysis reveals ACACA as a potential prognostic and immunotherapeutic biomarker across cancers
Our study establishes <i>ACACA</i> as a key metabolic regulator that links lipid metabolism to immune evasion and drug resistance, highlighting its potential as a promising therapeutic target across cancers.
Authors
- Yuze Wu (ORCID: https://orcid.org/0000-0002-8894-5118)
- Li‐Na Yi
- Fushan Gao
- H H He (ORCID: https://orcid.org/0000-0001-7934-6976)
- Leifeng Chen (ORCID: https://orcid.org/0000-0001-8305-1900)
- Fei Shao (ORCID: https://orcid.org/0000-0002-8742-9197)
- Jie He (ORCID: https://orcid.org/0009-0006-5954-0687)
- Zhen Zhang (ORCID: https://orcid.org/0000-0002-9898-054X)
- Yibo Gao (ORCID: https://orcid.org/0000-0003-1872-2135)
Institutions
- Nanchang University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wuhan University (CN)
- Henan Academy of Sciences (CN)
- Shanxi Provincial Cancer Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Renmin Hospital of Wuhan University (CN)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1599223
- Citations
- 1
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94