Tetramethylpyrazine exerts neuroprotective effects in a mouse model of acute hypobaric hypoxia
Our findings demonstrate that TMP provides significant neuroprotection under hypobaric hypoxia conditions. The mechanism is linked, at least in part, to the inhibition of the TREK-1 channel. These results position TMP as a promising therapeutic candidate for preventing or treating high-altitude-induced cognitive dysfunction.
Authors
- Yue Gao (ORCID: https://orcid.org/0000-0003-1131-5326)
- Zhijie Bai (ORCID: https://orcid.org/0000-0003-2231-1320)
- Wei Zhou (ORCID: https://orcid.org/0000-0003-0435-7261)
- Pan Shen (ORCID: https://orcid.org/0000-0001-8529-3727)
- Yue Sun (ORCID: https://orcid.org/0009-0007-4499-5221)
- Chengrong Xiao
- Chaoji Huangfu (ORCID: https://orcid.org/0000-0002-8650-7149)
- Huifang Deng (ORCID: https://orcid.org/0000-0002-0643-1974)
- Lei Zhou (ORCID: https://orcid.org/0000-0002-8164-0258)
- Zeng-Chun Ma (ORCID: https://orcid.org/0000-0003-4543-1974)
- Lan Xiong (ORCID: https://orcid.org/0000-0003-2760-8721)
- Ningning Wang
- Pengfei Zhang (ORCID: https://orcid.org/0000-0003-3306-4484)
Institutions
- Guangdong Pharmaceutical University (CN)
- Beijing Radiation Center (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fphar.2025.1662389
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 0.00