Aloe-emodin attenuates hyperuricemia-induced renal injury in mice by mitigating inflammation and oxidative stress
AOE effectively lowered serum UA levels, and exhibited renal protection in the PO/Ad-induced HUA mouse model by dampening inflammatory signaling and restoring redox equilibrium, likely through the PPAR and NF-κB pathways. This study demonstrated that AOE is a promising natural candidate with a desirable safety profile for treating HUA and renal injury, and more experimental validation are needed in the future.
Authors
- Daqun Liu
- Xiao Liu (ORCID: https://orcid.org/0000-0001-6053-132X)
- Guojun Jiang (ORCID: https://orcid.org/0000-0003-0596-854X)
- Shengfeng Wang (ORCID: https://orcid.org/0000-0001-9397-0409)
- Quanfeng Zhu
- Chengcheng Zhang (ORCID: https://orcid.org/0000-0002-0550-107X)
- Yan Chen (ORCID: https://orcid.org/0000-0002-1397-6358)
- Jiawen Yu (ORCID: https://orcid.org/0009-0004-9050-8103)
- Shuang Hu (ORCID: https://orcid.org/0000-0002-8316-7361)
Institutions
- Hangzhou Normal University (CN)
- Affiliated Hospital of Hangzhou Normal University (CN)
- ZheJiang Academy of Agricultural Sciences (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fnut.2025.1677560
- Citations
- 3
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 4.29