Mapping of chromatin architecture and enhancer-promoter interactions in the cochlea
This study establishes a high-resolution interaction map of the cochlea, demonstrating how non-coding variants can impair tissue-specific gene regulation in hearing loss. Our dataset provides a foundational resource for analyzing hereditary hearing loss mutations and investigating transcriptional regulation in the cochlea.
Authors
- Tuba Ege (ORCID: https://orcid.org/0000-0003-1574-171X)
- Celia Bloom
- Litao Tao (ORCID: https://orcid.org/0000-0002-9801-6515)
- Huizhan Liu (ORCID: https://orcid.org/0000-0003-2400-3284)
- Mi Ζhou (ORCID: https://orcid.org/0000-0002-2147-856X)
Institutions
- Creighton University (US)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fmolb.2025.1683964
- Citations
- 1
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.81