Red–Blue Light Therapy Mitigates Atopic Dermatitis via <scp>CD56bright NK</scp> Cell Modulation: A Mendelian Randomization Study
MR analysis confirmed the genetic association between CD56bright NK cells and AD, whereas scRNA-seq analysis highlighted their potential to inhibit AD progression. In vitro and in vivo experiments showed that red-blue light therapy promotes CD56bright NK cell growth by upregulating NKG2D, significantly improving AD symptoms.
Authors
- Xiaowen Wen (ORCID: https://orcid.org/0000-0001-9099-2987)
- Jian‐Fei Zhang
- Xuening Ma (ORCID: https://orcid.org/0009-0009-5871-4472)
- Shiyuan Wang (ORCID: https://orcid.org/0000-0002-5028-5839)
- Teng Yu
- Jing Wu (ORCID: https://orcid.org/0000-0002-6173-3254)
Institutions
- Shenzhen Pingle Orthopedic Hospital (CN)
Publication Details
- Journal
- Photodermatology Photoimmunology & Photomedicine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1111/phpp.70030
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00