Mass cytometric analysis of circulating immune landscape in primary central nervous system lymphoma
the circulating immune landscape in PCNSL is characterized by skewed monocyte activation, T cell terminal exhaustion, and chemotherapy-induced effector T cell expansion. Our findings link peripheral immune features to the tumor microenvironment biology. Understanding these systemic immune alterations may provide insights into tumor immune evasion and offer a roadmap for reversing PCNSL-associated immunosuppression.
Authors
- Liwei Lv
- Wenjing Wang (ORCID: https://orcid.org/0009-0005-6436-991X)
- Jing Liu (ORCID: https://orcid.org/0000-0002-8477-6572)
- Yuchen Wu (ORCID: https://orcid.org/0000-0003-1441-7192)
- Nan Ji (ORCID: https://orcid.org/0000-0002-9001-8858)
- Xuefei Sun
- Yuanbo Liu (ORCID: https://orcid.org/0000-0003-1703-6774)
- Shengjun Sun
- Chunji Gao
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Chinese General Hospital College of Nursing and Liberal Arts (PH)
- Beijing Tian Tan Hospital (CN)
- 307th Hospital of Chinese People’s Liberation Army (CN)
- The 309th Hospital of Chinese People's Liberation Army (CN)
- Beijing YouAn Hospital (CN)
- Chinese People's Liberation Army (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1658015
- Citations
- 2
- Primary Topic
- CNS Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.78