Mast cells are essential in the development of exposure-associated exercise-induced bronchoconstriction in a mouse model
Mast cells are crucial in the development of bronchial hyperreactivity and macrophage activation. Additionally, they have a complex interplay with neutrophilic inflammation. These findings highlight the potential of mast cell modulation as therapeutic strategy in exposure-associated EIB.
Authors
- Dominique Bullens (ORCID: https://orcid.org/0000-0002-4595-9579)
- Jonathan Cremer (ORCID: https://orcid.org/0000-0002-3793-8217)
- Jeroen Vanoirbeek (ORCID: https://orcid.org/0000-0001-5508-3518)
- Lieven Dupont (ORCID: https://orcid.org/0000-0003-3961-1522)
- Ellen Dilissen (ORCID: https://orcid.org/0000-0001-9837-8148)
- Nora F. Marain
- Marieke Colemont
- Fien Byttebier
Institutions
- Universitair Ziekenhuis Leuven (BE)
- Department of Public Health (MM)
- KU Leuven (BE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1650057
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00