Multi-omics analysis and evidence of IL1R1 as a potential biomarker for diabetes-associated intervertebral disc degeneration
These findings establish IL1R1 as a pivotal molecular bridge connecting T2DM and IDD, driven by neutrophil-mediated inflammation and NP cell dysfunction, offering novel diagnostic and therapeutic avenues.
Authors
- Wancheng Lin
- Jipeng Song
- Yukun Yin
- Shijie Liu (ORCID: https://orcid.org/0000-0001-6692-5522)
- Yao Zhang (ORCID: https://orcid.org/0009-0004-8822-9594)
- Lixiang Ding (ORCID: https://orcid.org/0000-0001-6179-6776)
- Meng Yi
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Cancer Center (US)
- Beijing Shijitan Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1692185
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00