CXCR7-TAGLN2 protein complex regulates invasion and metastasis in papillary thyroid carcinoma: a potential therapeutic target
CXCR7 and TAGLN2 are overexpressed in PTC and correlate closely with lymph node metastasis. CXCR7 may regulate PTC cell migration and invasion through interaction with TAGLN2, primarily by activating the TGF-β/Smad2 signaling pathway. The CXCR7-TAGLN2 protein complex represents a potential novel therapeutic target for PTC.
Authors
- Yubi Huang (ORCID: https://orcid.org/0000-0003-4323-7596)
- Rui Wang (ORCID: https://orcid.org/0000-0003-1723-4746)
- Hengwei Zhang (ORCID: https://orcid.org/0000-0001-5355-7257)
- Chao Zeng (ORCID: https://orcid.org/0000-0003-0808-9807)
Institutions
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1627419
- Citations
- 1
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.80