Real-world diagnostic value of integrating oral and ocular dryness testing in suspected Sjögren’s disease

Objective oral/ocular dryness testing, though rarely performed in routine rheumatologic care, is a valuable complement to serology and biopsy in diagnosing Sjögren's disease. While LSGB is essential for confirming classification in anti-Ro-negative subjects, it adds only modest value to meeting classification criteria in anti-Ro-positive subjects relative to contemporaneous glandular dryness testing. These findings support integrating objective dryness measures into routine diagnostic workflows to reduce reliance on invasive biopsies and improve diagnostic accuracy, especially in seropositive populations.