Brainstem neurochemical profiles after hospitalisation for COVID-19: a 7T MR spectroscopy study
We show the feasibility of assessing brainstem neurochemical profiles using 7T <sup>1</sup>H-MRS in a multi-centre study. Technical limitations at one site's 7T MRI led to variable repetition times, which limited our statistical power and should be avoided in future studies. Our findings highlight the need for further investigation into the role of neuroinflammation in post-acute COVID-19.
Authors
- Christopher T. Rodgers (ORCID: https://orcid.org/0000-0003-1275-1197)
- Carina Graf (ORCID: https://orcid.org/0000-0003-4281-3432)
- Stuart Clare
- Karen D. Ersche (ORCID: https://orcid.org/0000-0002-3203-1878)
- James B. Rowe (ORCID: https://orcid.org/0000-0001-7216-8679)
- Victoria Lupson
- Betty Raman (ORCID: https://orcid.org/0000-0002-1239-9608)
- Martyn Ezra (ORCID: https://orcid.org/0000-0002-6262-5247)
- Lin Qiu (ORCID: https://orcid.org/0000-0001-8419-1833)
- William T. Clarke (ORCID: https://orcid.org/0000-0003-1067-6250)
- Doris A. Chatfield
- Anne E. Manktelow (ORCID: https://orcid.org/0000-0002-2319-1669)
- Virginia Newcombe (ORCID: https://orcid.org/0000-0001-6044-9035)
- Stephen Sawcer (ORCID: https://orcid.org/0000-0001-7685-0974)
- Stefan Neubauer (ORCID: https://orcid.org/0000-0001-9017-5645)
- Joanne Outtrim (ORCID: https://orcid.org/0000-0001-8118-6430)
- Kyle T.S. Pattinson (ORCID: https://orcid.org/0000-0003-1353-2199)
- Mark Philip Cassar (ORCID: https://orcid.org/0000-0001-7192-6917)
- Rory McDonald (ORCID: https://orcid.org/0009-0005-4241-5065)
- Catarina Rua (ORCID: https://orcid.org/0000-0002-0404-4399)
- Edward T. Bullmore
- David K. Menon
Institutions
- MRC Cognition and Brain Sciences Unit (GB)
- Heidelberg University (DE)
- University of Cambridge (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Wellcome Centre for Integrative Neuroimaging (GB)
- Central Institute of Mental Health (DE)
- Oxford University Hospitals NHS Trust (GB)
- Perceptive Engineering (United Kingdom) (GB)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fnins.2025.1617709
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- NHS Blood and Transplant
- Wellcome Trust
- National Institute for Health and Care Research
- British Heart Foundation
- Department of Health and Social Care
- University of Oxford
- European Commission
- Rosetrees Trust
- Cambridge Trust
- Horizon 2020 Framework Programme
- NIHR BioResource
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre