Plasma exosomal lncRNA-related signatures define molecular subtypes and predict survival and treatment response in hepatocellular carcinoma
Plasma exosomal lncRNAs enable robust molecular subtyping, accurate prognostic stratification, and treatment response prediction in HCC. The ERG-centric classification system and validated 6-gene risk model provide clinically actionable tools for precision oncology.
Authors
- Lei Zhang (ORCID: https://orcid.org/0000-0003-2343-084X)
- Xiaozhong Wang (ORCID: https://orcid.org/0000-0001-8658-1931)
- Xinlu Wang (ORCID: https://orcid.org/0000-0003-1997-5687)
- Bo Huang (ORCID: https://orcid.org/0000-0002-3228-7662)
- Zihao Wang (ORCID: https://orcid.org/0009-0004-3331-7044)
- Fangyi Yao
- Jing Liu (ORCID: https://orcid.org/0000-0001-6595-2764)
- Fangmin Zhong
Institutions
- First Affiliated Hospital of Jiangxi Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1663943
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00